Apply
Apply, [a], is a command to 'use' an item. For example, you can apply a unicorn horn to remedy confusion, blindness, sickness, etc. You can also apply a pick-axe to break down a wall, a lamp to light it, a magic marker to write, etc.
Wands are used by zapping them, [z]. Applying a wand breaks it, causing an explosion that damages you and nearby monsters. You need to have a minimum strength of 10 to break a wand.